CUORiPS Inc, a portfolio company of Kyoto University Innovation Capital Corporation ("Kyoto-iCAP") (Head Office: Sakyo-ku, Kyoto; Representative Director: Kimi Kusumi), was listed on the Growth Market of the Tokyo Stock Exchange on June 27, 2023. CUORiPS's listing is the third listing among Kyoto-iCAP's portfolio companies.
CUORiPS is a regenerative medicine venture established in 2017 based on the results of joint research between the Kyoto University iPS Cell Research Institute (CiRA) and the Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine. The company's main product under development is a cardiac sheet for the treatment of heart failure made from induced pluripotent stem cells (iPS cells), a Kyoto University invention.
Currently, there are only limited effective treatments for severe heart failure, such as artificial hearts, but transplanting iPS cell-derived cardiac muscle sheets into patients' hearts is expected to dramatically improve symptoms. Osaka University and other institutions have been conducting a physician-led clinical trial for iPS cell-derived cardiac muscle sheets for ischemic severe heart failure since 2020, and CUORiPS has been responsible for manufacturing the cardiac muscle sheets used in this trial. In May of this year, the last subject in the clinical trial underwent transplantation, the first case in the world of regenerative medicine using iPS cells.
CUORiPS will be responsible for related work associated with the application for regulatory approval of iPS cell-derived cardiomyocyte sheets, as well as manufacturing and marketing after receiving approval. The company also plans to expand its business to Europe, the United States, and other Asian countries. Furthermore, the company has begun development of new catheter therapies and aims to grow into a comprehensive research and development biotech company targeting various heart diseases.

Outline of CUORiPS Inc.
Established March 2017
Business Development of novel therapeutic technologies for the heart
Head office location Chuo-ku, Tokyo
Representative Director Takayuki Kusanagi

Contact information for inquiries
Kyoto University Innovation Capital Co., Ltd.
36-1 Yoshida Honmachi, Sakyo-ku, Kyoto 606-8317, Japan
Osami Kono, Senior Officer, Business Development Department
TEL: 075-753-7588 FAX: 075-753-7592
E-mail: info@kyoto-unicap.co.jp